Best Serrapeptase Enzyme Blends
The serrapeptase benefits are well established in scientific serrapeptase research. But for many conditions like cardiovascular (heart) disease, deep vein thrombosis, diabetes, endometriosis, varicose veins and arthritis, combining serrapeptase with other potent enzymes will provide a much more effective treatment.
Serrapeptase enzyme blends generally work longer in the body than individual enzyme supplements, and many serrapeptase enzyme combinations significantly boost the fibrin-dissolving power of serrapeptase. This means that a strategically formulated serrapeptase enzyme blend can ultimately provide more serrapeptase benefits than taking serrapeptase by itself. However, not all serrapeptase enzyme blends are created equal.
Neprinol Versus Vitalzym
Neprinol and Vitalzym are two of the most popular serrapeptase enzyme blends on the market. But how do you know which is best? Choosing the best brand is all about comparing the serrapeptase enzyme content and fibrin-dissolving potential of each product before you buy serrapeptase enzyme blends. Let's compare Neprinol and Vitalzym head-to-head.
| Brand | Serrapeptase Activity per capsule | Other Fibrin-Dissolving Enzymes | Other Ingredients | Fillers |
| Neprinol | 45,000 SPU | Nattokinase, Bromelain, Papain, Fungal Protease | Lipase, Amla, Rutin, CoQ10, Magnesium | none |
| Vitalzym | 2,400 SPU | Bromelain, Papain | Lipase, Amla, Rutin, Amylase | Medium-chain triglycerides, starch, glycerin, polysacharrides, corn protein, beeswax, glycerin fatty acid ester, soy lecithin, citric acid |
As you can see in the chart above, the serrapeptase contained in one Neprinol capsule is nearly 20 times more powerful than the serrapeptase found in Vitalzym. This is extremely important since most of the clinical serrapeptase research showing the serrapeptase benefits used an average dose of 30,000-90,000 SPU per day (the same amount found in two Neprinol capsules). Therefore, even if 100% of the recommended dose of Vitalzym was absorbed by your body, it still wouldn't have enough serrapeptase enzyme activity to provide the clinical benefits described in serrapeptase research studies.
Neprinol also contains several other fibrin-dissolving/anti-inflammatory enzymes and coenzymes, most importantly nattokinase along with serrapeptase. Nattokinase is an enzyme extracted from a fermented soybean 'cheese' popular in Japan called natto [1]. Nattokinase's fibrin-dissolving potential has been tested in more than 12 scientific studies [2], and nattokinase has been shown to be the most powerful fibrin-degrading enzyme out of more than 200 foods, including bromelain and papain [3]. In fact, nattokinase has been shown to be four times more powerful than human plasmin, which is the enzyme responsible for breaking down fibrin and blood clots in our bodies [4].
Neprinol's powerful one-two punch of nattokinase and serrapeptase generally tests well above 30,000 FU (fibrin units) per gram, which means that 30,000 units of fibrin are broken down for each gram of Neprinol powder. Vitalzym, on the other hand, is much less potent since its formula contains less serrapeptase enzyme activity and no nattokinase. As a result, Neprinol is often recommended as the best serrapeptase enzyme blend.
Nattokinase-Serrapeptase Research
1. Sumi H, Hamada H, Tsushima H, Mihara H, Muraki H. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987;43:1110-1111.
2. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142.
3. Milner M, Makise K. Natto and its active ingredient nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap.2002;8(3):157-164.
4. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically-induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391.
